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Table of contents
- Fluorescence-Based Methods for Characterizing RNA Interactions In Vivo
- About this book
- Regulatory Rnas Basics Methods And Applications - unhatrooveltprep.ga
Recent progress in high-throughput technologies and genome-wide transcriptome studies have led to the significant scientific milestone of discovering non-coding RNAs ncRNAs , which span a major portion of the genome. Hence these RNA regulators are essential to the development of therapeutic or molecular medicine. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies microarray, next-gen sequencing etc.
The authors are internationally respected experts in the field of RNA biology.
Fluorescence-Based Methods for Characterizing RNA Interactions In Vivo
About this book
Here I present two novel methods for leveraging high-throughput sequencing in the study of short non-coding RNAs, as well as a study in which they are applied to Alzheimer's Disease AD. The computational methods presented here include High-throughput Annotation of Modified Ribonucleotides HAMR , which enables researchers to detect post-transcriptional covalent modifications to RNAs in a high-throughput manner.
When applied to the study of AD, it is apparent that several classes of non-coding RNAs, particularly tRNAs and tRNA fragments, show striking changes in the dorsolateral prefrontal cortex of affected human brains. Interestingly, the nature of these changes differs between mitochondrial and nuclear tRNAs, implicating an association between Alzheimer's disease and perturbation of mitochondrial function.
Regulatory Rnas Basics Methods And Applications - unhatrooveltprep.ga
In addition, by combining known genetic factors of AD with genes that are differentially expressed and targets of regulatory RNAs that are differentially expressed, I construct a network of genes that are potentially relevant to the pathogenesis of the disease. By combining genetics data with novel results from the study of non-coding RNAs, we can further elucidate the molecular mechanisms that underly Alzheimer's disease pathogenesis.
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